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楊曉洪，2019年6月在重慶大學(xué)藥學(xué)院獲博士學(xué)位，隨后進(jìn)入中科院重慶綠色智能技術(shù)研究院工作，主要從事基于天然產(chǎn)物的抗耐性新藥開發(fā)、工程化外泌體在抗感染性疾病治療中的應(yīng)用研究以及外泌體純化微球與精準(zhǔn)檢驗(yàn)新技術(shù)開發(fā)。主持國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目1項(xiàng)，重慶市自然科學(xué)基金面上項(xiàng)目1項(xiàng)，企業(yè)合作項(xiàng)目2項(xiàng)。在Angewandte Chemie，Journal of Medicinal Chemistry，Journal of Controlled Release等期刊上發(fā)表SCI論文30余篇，其中一作或共同一作論文14篇。

1. XH Yang, GM Shi, ZH Lin, YF Qiu, FY Liu, KC Hu, J Guo*, HB Peng*, Y He*. Pathogen-targeting biomineralized bacterial outer membrane vesicles for eradicating both intracellular and extracellular Staphylococcus aureus[J]. J. Control. Release, 2025, 382, 113702.

2. XH Yang, ZP Wang, SC Xiang, DQ Wang, Y Zhao, D Luo, YF Qiu, C Huang, J Guo, YW Dai, SL Zhang^*, Y He^*. Optimization of the natural product Calothrixin A to discover novel dual Topoisomerase I and II inhibitors with improved anticancer activity[J]. J. Med. Chem, 2022, 65, 8040-8061. ?

3. XH Yang, BB Xie, HB Peng, GM Shi, J Guo, CH Wang^*, Y He^*. Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes[J]. J. Control. Release, 2021, 329, 454-467.

4. XH Yang, GM Shi, J Guo, CH Wang*, Y He*. exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus[J]. Int J Nanomed, 2018, 13, 8095-8104.

5. HB Peng, BB Xie, JJ Dai, YW Dai, XF Cen, XH Yang^*, Y He^*. Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar [5] arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus [J]. Mater. Chem. Front., 2022, 6, 360-367.

6. GM Shi^#, XH Yang^#, JK Wang, WJ Wei, KC Hu, XY Huang, YF Qiu, Y He*. Isolation of extracellular outer membrane vesicles (OMVs) from Escherichia coli using EVscore47 beads. Molecules, 2024, 29(8), 1831.

7. BB Xie^#, XH Yang^#, RX Zhang, J Guo, Z Chen, Y He^*. Hollow and porous Fe₃C-NC nanoballoons nanozymes for cancer cell H₂O₂ detection. Sensor Actuat B-Chem, 2021, 347, 130597.

8. S Chen^#, XH Yang^#, Y Zhang, Y Liu, H Lu, Y Qiu, C Wang*. Inhalable porous microspheres loaded with metformin and docosahexaenoic acid suppress tumor metastasis by modulating premetastatic niche[J]. Mol Pharmaceutics, 2021, 18(7), 2622-2633.

9. L Peng^#, D Xu^#, XH Yang^#, JK Tang^#, XL Feng^*, S-L Zhang^*, HL Yan^*. Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation[J]. Angewandte Chemie, 2019, 131(1), 222-226 .

10. Q Liu^#, XH Yang^#, J Ji, S-L Zhang^*, Y He^*. Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structureeactivity relationship studies[J]. Eur J Med Chem, 2019, 170, 99-111.